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Clobetasone butyrate
CAS No. 25122-57-0
Clobetasone butyrate( —— )
Catalog No. M24140 CAS No. 25122-57-0
Clobetasone butyrate can be used to relieve corticosteroid-responsive dermatoses, including atopic?dermatitis and psoriasis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | 68 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameClobetasone butyrate
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NoteResearch use only, not for human use.
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Brief DescriptionClobetasone butyrate can be used to relieve corticosteroid-responsive dermatoses, including atopic?dermatitis and psoriasis.
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DescriptionClobetasone butyrate can be used to relieve corticosteroid-responsive dermatoses, including atopic?dermatitis and psoriasis. Clobetasone butyrate is a synthetic glucocorticoid. It has topical anti-inflammatory activity especially in skin .
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In Vitro——
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In VivoClobetasone butyrate (application on the skin; 0.05%; 7 weeks) induces epidermal thinning in skin, Clobetasone butyrate 7 weeks causes much less epidermal thinning in the pig than flurandrenolone (0.05%) or fluocinolone acetonide (0.025%), both of which causes severe atrophy. Animal Model:Large white domestic pigDosage:0.5% application on the skin Administration:7 weeks Result:Caused moderate to slight atrophy.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptorglucocorticoid
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Research Area——
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Indication——
Chemical Information
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CAS Number25122-57-0
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Formula Weight478.98
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Molecular FormulaC26H32ClFO5
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Purity>98% (HPLC)
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SolubilityDMSO:240 mg/mL (501.06 mM)
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SMILESC[C@@]1(C2)[C@](C(CCl)=O)(OC(CCC)=O)[C@@H](C)C[C@@]1([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3(F)C2=O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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ZLDI-8
ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein.ZLDI-8;?it inhibited the cleavage of NOTCH protein, consequently decreased the expression of pro-survival/anti-apoptosis and EMT related proteins.?
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FG 7142
FG 7142?also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM).?FG 7142?can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex.?FG 7142 , a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM).?
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ASC-JM-17
ASC-JM-17 is an activator of both Nrf1 and Nrf2 proteins. ASC-JM17 acts on Nrf1, Nrf2 and Hsf1 to increase the expression of proteasome subunits, antioxidant enzymes and molecular chaperones.
